My all time favorite comic series has to be Sam & Max. If you ever read it (or played the PC game) you'l know why. A similar book is Snake n' Bacon's cartoon cabaret, lots of randomness and pop culture references (think family guy, but actually funny with 100% less fail and with no pretense of plot) with a lot of really memorable short jokes. I recommend everyone who likes humor pick it up, I got mine for 10 bucks. Here's a sample courtesy of google image search:
The whole book is like that, except funnier.
One of the only action comics I've ever read and liked was The Punisher. It's like a paper form of alot of cheesy action movies (Rambo, Army of Darkness, etc, my favorite type of film), with zero depth, a total asshole for a main character and tons of ass-kicking and badass one-liners. I don't really have the desire to check out any other comics because there's so damn many of them and from what I've heard of Marvel and DC there's a lot of continuity problems and nothing I've seen so far looks very original or interesting enough to pursue. I also read a comic called Witchblade, thought it was pretty amusing but I'm not going to read the whole series.